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• Other channels that are supplement to the EEG channels and other relevant information that are available in the datasets.
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Most modern TBI biomarker studies have investigated the individual prediction abilities of different molecules. The studies show that single biomarkers tend to have low specificities when sensitivity is set above 90%. Therefore, individual blood-based biomarkers may not be applicable for clinical practice as stand-alone tools (19, 28, 31), which is expected due to the complexity of TBI. Combining several biomarkers or combining biomarkers with clinical characteristics have been suggested to improve diagnostic and predictive abilities (31, 32). Thus, biomarkers may provide additional value in outcome prediction of TBI when used in combination with predictive neuroimaging scores. However, studies on blood-based biomarkers complementing head imaging scores are scarce.

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• The CHB‐MIT Scalp EEG dataset consists of long‐term and short‐term continuous data in segments depending on the patients.

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IMPACT data were added in regression by the insert model, which forces the entry of all variables. In addition, the scores were added in a second block to evaluate its increment in the standard model. To systematize and stratify TBI patients based on CT imaging characteristics, several classification systems have been proposed; the most popular used in practice are Marshall CT classification and Rotterdam and Helsinki CT scores. The lower limits of detection, the lower limits of quantification, and the calibration ranges for the blood-based biomarkers are shown in Supplementary Table 1. One patient had an S100B level below the lower limit of detection range, and therefore, the concentration of 1 pg/ml was applied, permitting statistical analysis.

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• Sampling frequency of the datasets can also be found in Table 8.
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Several brain-enriched protein biomarkers have been studied in combination and isolation as tools for predicting TBIs of different severities (16–18). Biomarkers may offer incremental value in outcome prediction when used in combination with neuroimaging scores. We found that panels of biomarkers significantly outperformed individual biomarkers in this setting (19). The Pin Up Aviator app is not just about accessibility; it’s also about delivering an exceptional user experience.

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The discretely higher Rotterdam CT AUC value was not statistically significant when compared to the Helsinki CT, and p values for the comparison are presented in Supplementary Table S1. Receiver operating characteristic curves for prediction of (A) 14-day mortality and (B) in-hospital mortality. Lastly, like the other temporal properties, the sampling frequency also varies across the datasets. The remaining datasets have constant sampling frequency within the dataset, with the highest sampling frequency of 512 Hz in Siena Scalp EEG and the lowest in the University of Bonn at 173.6 Hz. Sampling frequency of the datasets can also be found in Table 8.

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• The remaining datasets have constant sampling frequency within the dataset, with the highest sampling frequency of 512 Hz in Siena Scalp EEG and the lowest in the University of Bonn at 173.6 Hz.
• Receiver operating characteristic curves for prediction of (A) 14-day mortality and (B) in-hospital mortality.
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52 In our study, the effect of this bias is minimal, as we were only interested in how many of the studies use the data rather than the results themselves. Based on Table 8, the number of seizure events is largely affected by the total size of the dataset (Total recorded segments x recordings length per segment).

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These algorithms may also help alert caregivers of impending seizures at home. 8 , 9 EEG‐based seizure detection and prediction algorithms proposed by studies over the past 5 years have largely relied on publicly available EEG‐based datasets.

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• To better illuminate the predictive power of biomarkers in patients with CT-positive findings, we also investigated their abilities in distinguishing between patients with complete and incomplete recovery.
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